Temulin-D

Temulin-D contains tiamulin-D hydrogen fumarate (thf), a semi-synthetic derivative of the naturally occurring antibiotic pleuromutilin, which is derived from the fungus Pleurotus mutilus. The molecule is only used in veterinary medicine and this is the reason the use in animal health has a low risk for human medicine (EMEA report, 1999; Alban et al., 2017). Further it contains Chlortetracycline (CTC) which belongs to tetracycline group of antibiotics. Both the antibiotics have synergistic effect. Temulin-D exerts its action by bonding to the subunit 50 S of the bacterial ribosome. It appears that its mechanism of action consists of the production of biochemically inactive initiation complexes that impede the elongation of the polypeptide chain. Thus, it acts as a bacteriostatic at therapeutic concentrations.